Inhibition of influenza virus uncoating by rimantadine hydrochloride.
نویسندگان
چکیده
In freeze-thaw lysates of MDCK cells infected with 32P-labeled influenza virus A/WSN in the presence of added RNase, acid-precipitable radioactivity diminished to about 50% of initial values within 90 min after a 1-h virus adsorption period. A similar preparation containing rimantadine at a concentration of 50 micrograms/ml exhibited only a 10% reduction in acid-precipitable radioactivity. These findings suggest that rimantadine interferes with uncoating of influenza virus in infected cells.
منابع مشابه
Different modes of inhibition by adamantane amine derivatives and natural polyamines of the functionally reconstituted influenza virus M2 proton channel protein.
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عنوان ژورنال:
- Journal of virology
دوره 31 1 شماره
صفحات -
تاریخ انتشار 1979